Go 6976 |CAS:136194-77-9 Probechem Biochemicals

Chemical Structure : Go 6976

CAS No.: 136194-77-9

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Go 6976 (Go-6976;Go6976)

货号: PC-60684Not For Human Use, Lab Use Only.

Go 6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively.

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2 mg	￥1480	In stock
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Go 6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively.
Go 6976 shows no effect on the kinase activity of PKCδ, -ε and -ζ (IC50>3 uM).
Go 6976 also inhibits JAK2, FLT3 and mutant FLT3 with significant activity in primary acute myeloid leukaemia cells.
Go 6976 inhibits HIV-1 proviral induction from latent/low-level-producing infectious states, inhibits signalling, survival and proliferation in cells expressing the leukaemia-associated TEL-JAK2 fusion protein and the MPD-associated JAK2 V617F mutant.

物理化学性质&存储条件

分子量	378.43
分子式	C24H18N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile

参考文献

1. Martiny-Baron G, et al. J Biol Chem. 1993 May 5;268(13):9194-7.

2. Qatsha KA, et al. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4674-8.

3. Pätzold S, et al. Antiviral Res. 1993 Dec;22(4):273-83.

4. Grandage VL, et al. Br J Haematol. 2006 Nov;135(3):303-16.

Go 6976 (Go-6976;Go6976)

生物&药学活性

物理化学性质&存储条件

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Go 6976 (Go-6976;Go6976)

生物&药学活性

物理化学性质&存储条件

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