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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Receptor-GlyphAllo
GlyphAllo

Chemical Structure : GlyphAllo

CAS No.: 2681264-65-1

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GlyphAllo (SPT-300, SPT300, Glyph Allopregnanolone)

货号: PC-28340Not For Human Use, Lab Use Only.

GlyphAllo (SPT-300, Glyph Allopregnanolone) is an oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport, shows neuroactive steroid antidepressant and anxiolytic activity via GABAA (γ-aminobutyric acid type A) receptor positive allosteric modulation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GlyphAllo (SPT-300, Glyph Allopregnanolone) is an oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport, shows neuroactive steroid antidepressant and anxiolytic activity via GABAA (γ-aminobutyric acid type A) receptor positive allosteric modulation.

物理化学性质&存储条件

分子量 847.14
分子式 C48H78O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((((((3R,5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)carbonyl)oxy)methyl) 5-(1,3-bis(octanoyloxy)propan-2-yl) 3-methylpentanedioate

参考文献

1. Simpson JS, et al. Sci Transl Med. 2026 Mar 25;18(842):eadu2352.

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