Glutipyran

Chemical Structure : Glutipyran

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货号: PC-47016Not For Human Use, Lab Use Only.

Glutipyran is a small-molecule glucose transporter inhibitor, inhibits glycolytic activity and cell growth in human pancreatic cancer cells.

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25 mg		Get quote
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生物&药学活性

Glutipyran is a small-molecule glucose transporter inhibitor, inhibits glycolytic activity and cell growth in human pancreatic cancer cells.
Glutipyran inhibited glucose uptake and suppressed the growth of various cancer cells, including A431 cells that express glucose transporter class I (GLUT1) and DLD-1 GLUT1 knockout cells.
Glutipyran exhibited a synergistic antiproliferative effect, when combined with the mitochondrial respiration inhibitor metformin.
Glutipyran markedly decreased most metabolites of the glycolytic pathway and the pentose phosphate pathway.
Glutipyran significantly suppressed tumor growth in a xenograft mouse model of pancreatic cancer.

物理化学性质&存储条件

分子量	491.628
分子式	C30H37NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,4-dimethoxybenzyl)-N-((R)-3-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-phenylpropyl)furan-2-carboxamide

参考文献

1. Makoto Kawatani, et al. ACS Chem Biol. 2021 Aug 20;16(8):1576-1586.

Glutipyran

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物理化学性质&存储条件

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Glutipyran

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