GluN2A PAM Y36

Chemical Structure : GluN2A PAM Y36

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货号: PC-25186Not For Human Use, Lab Use Only.

GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%.

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生物&药学活性

GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%.
Y36 showed higher efficacy (Emax = 397.7%) than GNE-3419 (Emax = 196.4%), reducing the EC50 values and increasing the Emax values for glutamate/glycine at GluN2A receptor.
Y36 significantly alleviated depression-related behaviors in multiple behavioral assessments in chronic restraint stress (CRS) mice.
Y36 has favorable pharmacokinetic (PK) profiles and blood-brain barrier (BBB) penetration, with no signs of addiction, weight gain, or organ and tissue damage in mice.

物理化学性质&存储条件

分子量	373.45
分子式	C19H20FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

参考文献

1. Tingting Yang, et al. J Med Chem. 2025 Jul 31. doi: 10.1021/acs.jmedchem.5c01173.

GluN2A PAM Y36

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GluN2A PAM Y36

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