GluN2A PAM (R)-9 | GluN2A PAM | Probechem Biochemicals

Chemical Structure : GluN2A PAM (R)-9

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GluN2A PAM (R)-9 (GluN2A positive allosteric modulator (R)-9)

货号: PC-20368Not For Human Use, Lab Use Only.

GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%.

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生物&药学活性

GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%.
GluN2A PAM (R)-9 shows good NMDA-subtype selectivity, with>59-fold selectivity for GluN2B and 2C and 19-fold selectivity for GluN2D in the Ca2+ influx assay using CHO cells.
GluN2A PAM (R)-9 (10 mg/kg) significantly enhances long-term potentiation in the rat hippocampus 24 h after oral administration.

物理化学性质&存储条件

分子量	380.78
分子式	C16H15ClF2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(2-((5-Chloro-3-(difluoromethyl)-1H-pyrazol-1-yl)methyl)-7-methyl-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)butanenitrile

参考文献

1. Sakurai F, et al. Bioorg Med Chem. 2022 Feb 15;56:116576.

GluN2A PAM (R)-9 (GluN2A positive allosteric modulator (R)-9)

生物&药学活性

物理化学性质&存储条件

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GluN2A PAM (R)-9 (GluN2A positive allosteric modulator (R)-9)

生物&药学活性

物理化学性质&存储条件

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