Gliotoxin | LTA4 hydrolase inhibitor | Probechem Biochemicals

Chemical Structure : Gliotoxin

CAS No.: 67-99-2

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Gliotoxin (Aspergillin)

货号: PC-21193Not For Human Use, Lab Use Only.

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2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

Gliotoxin (Aspergillin) is a virulence factor of Aspergillus fumigatus, functions as a potent and selective inhibitor of the epoxide hydrolase activity of LTA4 hydrolase (LTA4H), selectively inhibits LTB4 biosynthesis.
Gliotoxin selectively suppresses LTB4 biosynthesis and blocks neutrophil recruitment in vivo.
Gliotoxin potently and selectively inhibits LTB4 biosynthesis in human neutrophils and monocytes (IC50=0.8 uM).
Gliotoxin efficiently reduces LTB4 formation but failed to inhibit the aminopeptidase activity up to 10 μM in human neutrophils.
Gliotoxin causes specific suppression of LTB4 biosynthesis without inhibiting the formation of additional products from the same substrate (i.e., LTA4) or related LMs generated by other enzymatic eicosanoid pathways.

物理化学性质&存储条件

分子量	326.39
分子式	C13H14N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxyMethyl)-2-Methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione

参考文献

1. König S, et al. Cell Chem Biol. 2019 Apr 18;26(4):524-534.e5.

Gliotoxin (Aspergillin)

生物&药学活性

物理化学性质&存储条件

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Gliotoxin (Aspergillin)

生物&药学活性

物理化学性质&存储条件

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