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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Glibenclamide
Glibenclamide

Chemical Structure : Glibenclamide

CAS No.: 10238-21-8

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Glibenclamide (Glyburide)

货号: PC-21736Not For Human Use, Lab Use Only.

Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor, directly binds and blocks the SUR1 subunits of KATP.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor, directly binds and blocks the SUR1 subunits of KATP.
Glibenclamide inhibits P-glycoprotein and the cystic fibrosis transmembrane conductance regulator protein (CFTR).
Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability.

物理化学性质&存储条件

分子量 494.00
分子式 C23H28ClN3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

参考文献

1. Heo R, et al. Life Sci. 2021;283:119868.

2. Fernandes MA, et al. J Biochem Mol Toxicol. 2004;18(3):162-169.

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