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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Glecaprevir
Glecaprevir

Chemical Structure : Glecaprevir

CAS No.: 1365970-03-1

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Glecaprevir (ABT-493, A1282576)

货号: PC-61941Not For Human Use, Lab Use Only.

Glecaprevir (ABT-493, A1282576) is a potent HCV NS3/4A protease inhibitor with pan-genotypic activity, inhibits NS3/4A proteases from HCV genotypes 1-6 in vitro with IC50 of 3.5-11.3 nM.

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25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Glecaprevir (ABT-493, A1282576) is a potent HCV NS3/4A protease inhibitor with pan-genotypic activity, inhibits NS3/4A proteases from HCV genotypes 1-6 in vitro with IC50 of 3.5-11.3 nM.
Glecaprevir inhibits the replication of stable HCV subgenomic replicons genotypes 1-6 with EC50 of 0.21-4.6 nM, has a median EC50 of 0.30 nM (0.05 - 3.8 nM) for HCV replicons containing proteases from 40 HCV genotype 1-5 samples.
The combination of ABT-493 and ABT-530 demonstrates potent antiviral activity and acceptable safety in clinical trails with HCV genotype 1 infection.

物理化学性质&存储条件

分子量 838.87
分子式 C38H46F4N6O9S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(33R,35S,91R,92R,5S,E)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35

参考文献

1. Lawitz EJ, et al. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1546-55.

2. Gane E, et al. Gastroenterology. 2016 Oct;151(4):651-659.e1.

3. Poordad F, et al. Hepatology. 2017 Aug;66(2):389-397.

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