Glabrescione B (GlaB)

Chemical Structure : Glabrescione B

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货号: PC-63516Not For Human Use, Lab Use Only.

Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function.

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生物&药学活性

Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function.
Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors.
Glabrescione B inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells.
Glabrescione B inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo.

物理化学性质&存储条件

分子量	450.531
分子式	C27H30O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[3,4-bis(3-methylbut-2-enoxy)phenyl]-5,7-dimethoxychromen-4-one

参考文献

1. Infante P, et al. EMBO J. 2015 Jan 13;34(2):200-17.

2. Ingallina C, et al. Nanomedicine (Lond). 2017 Apr;12(7):711-728.