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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-Girolline
Girolline

Chemical Structure : Girolline

CAS No.: 110883-46-0

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Girolline (Girodazole)

货号: PC-23755Not For Human Use, Lab Use Only.

Girolline (Girodazole) is a sequence-selective modulator of translation factor eIF5A, interferes with ribosome-eIF5A interaction and induces ribosome stalling, an anti-tumor agent as well as having activity against malaria.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Girolline (Girodazole) is a sequence-selective modulator of translation factor eIF5A, interferes with ribosome-eIF5A interaction and induces ribosome stalling, an anti-tumor agent as well as having activity against malaria.

物理化学性质&存储条件

分子量 190.63
分子式 C6H11ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2S)-3-amino-1-(2-amino-1H-imidazol-4-yl)-2-chloropropan-1-ol

参考文献

1. Schneider-Poetsch T, et al. Nat Commun. 2025 Jan 10;16(1):223.

2. Fung SY, et al. ACS Chem Biol. 2014 Jan 17;9(1):247-57.

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