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首页-抗体和重组蛋白-Biosimilar Antibody-Girentuximab
Girentuximab

Chemical Structure : Girentuximab

CAS No.: 916138-87-9

Girentuximab (Anti-human Carbonic anhydrase IX mAb, human IgG1-Kappa; WX-G250)

货号: PC-Ab1117Not For Human Use, Lab Use Only.

Girentuximab (G250) is a monoclonal antibody (mAb) for targeting CA IX, a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). Carbonic anhydrase IX (CA IX) is the most widely expressed gene in response to hypoxia. Its crucial role in intracellular pH maintenance represents the means by which cancer cells adapt to the toxic conditions of the extracellular milieu..

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5 mg ¥7580 In stock
10 mg ¥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Girentuximab (G250) is a monoclonal antibody (mAb) for targeting CA IX, a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). Carbonic anhydrase IX (CA IX) is the most widely expressed gene in response to hypoxia. Its crucial role in intracellular pH maintenance represents the means by which cancer cells adapt to the toxic conditions of the extracellular milieu.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

Girentuximab; Chimeric-monoclonal-antibody-G250; Monoclonal antibody G250; Rencarex; WX-G250; 916138-87-9; Anti-human Carbonic anhydrase IX; Anti-human CA IX; carbonic anhydrase 9

参考文献

1. 1, Chamie K, et al. JAMA Oncol. 2017 Jul 1;3(7):913-920. 2, Hekman MCH, et al. Eur Urol. 2018 Sep;74(3):257-260.  3, Déas O, et al. Hum Gene Ther. 2002 Jun 10;13(9):1101-14. 4, Bleumer I, et al. Br J Cancer. 2004 Mar 8;90(5):985-90. 

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