Ginsenoside compound K (Ginsenoside C-K, Ginsenoside K)

Chemical Structure : Ginsenoside compound K

CAS No.: 39262-14-1

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货号: PC-28727Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥780	In stock
50 mg	￥1180	In stock
100 mg	￥1780	In stock
250 mg		Get quote

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生物&药学活性

Ginsenoside compound K (GCK, Ginsenoside C-K, Ginsenoside K) is a deglycosylated ginsenoside metabolite with anti-inflammatory, vascular-protective and anticancer properties, targets DUSP5 to inhibit the malignant progression of glioblastoma, also inhibits PRELID3B (Kd=23 uM) to inhibit lung cancer.
Ginsenoside compound K (GCK, Ginsenoside C-K) inhibits complement C1qA/C3-CR3-mediated microglial synaptic pruning and neuronal pyroptosis.
Ginsenoside compound K (GCK, Ginsenoside C-K) inhibits and stabilizes PRELID3B in cellular thermal shift assay and bind PRELID3B with Kd of 23 uM.
Ginsenoside compound K (GCK, Ginsenoside C-K) markedly inhibited the proliferation and migration of glioblastoma cells and significantly disrupted their cell cycle.
Ginsenoside compound K (GCK, Ginsenoside C-K) suppresses glioblastoma progression by dephosphorylating p-ERK1/2 via upregulation of DUSP5 expression.
Ginsenoside compound K (GCK, Ginsenoside C-K) exerts osteoprotective effects by suppressing osteoclastogenesis and promoting preosteoclast PDGF-BB-induced angiogenesis via targeting CSF1R.
Ginsenoside compound K (GCK, Ginsenoside C-K) exhibits anti-inflammatory effects by reducing iNOS and COX-2. suppresses cancerous cell proliferation, and the safeguarding of cardiovascular, hepatic, and renal functions.

物理化学性质&存储条件

分子量	622.88
分子式	C36H62O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylhept-5-en-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

参考文献

1. He J, et al. Proc Natl Acad Sci U S A. 2026 May 12;123(19):e2533505123.

2. Zhao X, et al. J Ethnopharmacol. 2026 Oct 18;374(Pt 3):122537.

3. Tang F, et al. Eur J Pharmacol. 2026 Mar 28;1019:178678.