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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Myosin-Ginsenoside Ra1
Ginsenoside Ra1

Chemical Structure : Ginsenoside Ra1

CAS No.: 83459-41-0

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Ginsenoside Ra1 (Ginsenoside-Ra1)

货号: PC-28615Not For Human Use, Lab Use Only.

Ginsenoside Ra1 is a dammarane-type bisdesmosidic saponin in the roots of Panax ginseng and potent on-muscle myosin heavy chain IIA (NMMHC IIA) inhibitor, shows significant inhibitory effect on protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation (H/R).

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5 mg ￥1780 In stock
10 mg ￥2780 In stock
25 mg ￥4780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ginsenoside Ra1 is a dammarane-type bisdesmosidic saponin in the roots of Panax ginseng and potent on-muscle myosin heavy chain IIA (NMMHC IIA) inhibitor, shows significant inhibitory effect on protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation (H/R).
Ginsenoside Ra1 binds to strongly to NMMHC IIA, whose knockdown ameliorated sepsis-induced endothelial barrier disruption and multi-organ injury (lung, intestine, liver and kidney).
Ginsenoside Ra1 attenuates mortality, hypothermia, multi-organ injury, vascular hyperpermeability and endothelial junction disruption in septic mice.

物理化学性质&存储条件

分子量 1211.40
分子式 C58H98O26
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S,4S,5R,6S)-2-((((2S,3R,4R,5S)-3,4-Dihydroxy-5-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-6-(((S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-(((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-12-hydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylhept-5-en-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-tr

参考文献

1. Dou DQ, et al. Planta Med. 2001 Feb;67(1):19-23.

2. Tang J, et al. Br J Pharmacol. 2026 Oct 13. doi: 10.1111/bph.70689.

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