GiGA1 | GIRK1/2 activator | Probechem Biochemicals

Chemical Structure : GiGA1

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GiGA1 (G-protein-independent GIRK channel activator 1)

货号: PC-23631Not For Human Use, Lab Use Only.

GiGA1 is a selective G-protein-independent activator of GIRK channels, targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM.

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生物&药学活性

GiGA1 is a selective G-protein-independent activator of GIRK1/2 channels targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM.
GiGA1 exhibits high specificity for activating GIRK1/GIRK2 channels, GiGA1 activaiton of GIRK1/GIRK2 channels, does saturate at ~100 μM.
GiGA1 exhibits little to no activity against GIRK2/GIRK3, GIRK1/GIRK3, and GIRK1/GIRK4 channels expressed in HEK293T cells.
GiGA1 induces GIRK currents in hippocampal CA1 pyramidal neurons, which express mostly GIRK1/GIRK2 heterotetramers.
GiGA1 (20, 40, or 60 mg/ kg) exhibited antiseizure properties in an in vivo epilepsy model.

物理化学性质&存储条件

分子量	232.30
分子式	C12H12N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(thiophen-2-yl)-3-(o-tolyl)urea

参考文献

1. Zhao Y, et al. Cell Rep. 2020 Jun 16;31(11):107770.

GiGA1 (G-protein-independent GIRK channel activator 1)

生物&药学活性

物理化学性质&存储条件

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GiGA1 (G-protein-independent GIRK channel activator 1)

生物&药学活性

物理化学性质&存储条件

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