Ghrelin agonist HM01

Chemical Structure : Ghrelin agonist HM01

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货号: PC-35623Not For Human Use, Lab Use Only.

Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM.

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生物&药学活性

Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM.
HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats.
HM01 also attenuates cachexia in mice bearing bolon-26 (C26) tumors.

物理化学性质&存储条件

分子量	402.36
分子式	C19H29Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-Methyl-3,3-dimethyl-4-piperidyl]urea

参考文献

1. Rudd JA, et al. Front Pharmacol. 2018 Aug 6;9:869.

2. Karasawa H, et al. Neurogastroenterol Motil. 2014 Dec;26(12):1771-82.

3. Villars FO, et al. Int J Mol Sci. 2017 May 5;18(5). pii: E986.