Gerfelin |CAS:627545-07-7 Probechem Biochemicals

Chemical Structure : Gerfelin

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Gerfelin (Glyoxalase I inhibitor, GLO1 inhibitor)

货号: PC-62075Not For Human Use, Lab Use Only.

Gerfelin is an osteoclastogenesis inhibitor (IC50=61 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.15 uM.

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生物&药学活性

Gerfelin is an osteoclastogenesis inhibitor (IC50=61 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.15 uM.
Gerfelin shows weak inhibitory effect due to poor cell permeability compared with Methyl gerfelin.
Gerfelin also inhibits P. falciparum GLO1.

物理化学性质&存储条件

分子量	290.271
分子式	C15H14O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoic acid

参考文献

1. Zenitani S, et al. J Antibiot (Tokyo). 2003 Jul;56(7):617-21.

2. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.

3. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.

Gerfelin (Glyoxalase I inhibitor, GLO1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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Gerfelin (Glyoxalase I inhibitor, GLO1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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