Genz 669178 |CAS:1254834-91-7 Probechem Biochemicals

Chemical Structure : Genz 669178

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Genz 669178 (Genz669178)

货号: PC-70340Not For Human Use, Lab Use Only.

Genz 669178 is a potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.

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1 g		Get quote

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生物&药学活性

Genz 669178 is a potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
Genz 669178 demonstrates in vitro potency against the 3D7 and Dd2 strains of P. falciparum.
Genz 669178 shows good tolerability and oral exposure in the mouse, and ED(50) values in the 4-day murine P. berghei efficacy model of 13-21 mg/kg/day with oral twice-daily dosing.

物理化学性质&存储条件

分子量	322.386
分子式	C17H14N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-cyano-2-methyl-1H-benzo[d]imidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide

参考文献

1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.

2. Booker ML, et al. J Biol Chem. 2010 Oct 22;285(43):33054-64.

3. Skerlj RT, et al. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13.

Genz 669178 (Genz669178)

生物&药学活性

物理化学性质&存储条件

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Genz 669178 (Genz669178)

生物&药学活性

物理化学性质&存储条件

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