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首页-小分子抑制剂&激动剂-Others-Other Targets-Genz-123346
Genz-123346

Chemical Structure : Genz-123346

CAS No.: 943344-58-9

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Genz-123346 (Genz123346)

货号: PC-43171Not For Human Use, Lab Use Only.

Genz-123346 is a potent, specific glucosylceramide synthase (GCS) inhibitor with IC50 of 14 nM (GM1 inhibition), does not inhibit α-glucosidase or glucocerebrosidase and little effect on 1-O-acylceramide synthase activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Genz-123346 is a potent, specific glucosylceramide synthase (GCS) inhibitor with IC50 of 14 nM (GM1 inhibition), does not inhibit α-glucosidase or glucocerebrosidase and little effect on 1-O-acylceramide synthase activity.
    Genz-123346 effectively inhibits GL1 synthase activity and does not significantly elevate cell ceramide levels in vitro, lowers glucose and A1C levels.
    Genz-123346 improves glucose tolerance in the Zucker diabetic fatty rats.
    Genz-123346 effectively inhibits cystogenesis in mouse models of polycystic kidney disease (PKD).

    物理化学性质&存储条件

    分子量 987.2259
    分子式 C52H82N4O14
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Nonanamide, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)

    参考文献

    1. Zhao H, et al. Diabetes. 2007 May;56(5):1210-8.

    2. Zhao H, et al. Hepatology. 2009 Jul;50(1):85-93.

    3. Natoli TA, et al. Nat Med. 2010 Jul;16(7):788-92.

    4. Chai L, et al. Int J Oncol. 2011 Mar;38(3):701-11.

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