Genipin | UCP2 inhibitor | Probechem Biochemicals

Chemical Structure : Genipin

CAS No.: 6902-77-8

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Genipin ((+)-Genipin)

货号: PC-23649Not For Human Use, Lab Use Only.

Genipin is a specific small molecule inhibitor of uncoupling protein 2 (UCP2), inhibits UCP2-mediated mitochondrial proton leak.

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25 mg	￥380	In stock
100 mg	￥780	In stock
250 mg	￥1180	In stock
1 g		Get quote

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生物&药学活性

Genipin is a specific small molecule inhibitor of uncoupling protein 2 (UCP2), inhibits UCP2-mediated mitochondrial proton leak.
Genipin does not scavenge superoxide. Genipin inhibits HNE-activated, UCP2-mediated mitochondrial proton leak.
Genipin does not affect other mitochondrial transport functions in liver mitochondria.
Genipin increases mitochondrial membrane potential, increases ATP levels, closes KATP channels, and stimulates insulin secretion in a UCP2-dependent manner.
Genipin reverses high glucose- and obesity-induced β cell dysfunction.

物理化学性质&存储条件

分子量	226.23
分子式	C11H14O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,4aS,7aS)-Methyl 1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate

参考文献

1. Zhang CY, et al. Cell Metab. 2006 Jun;3(6):417-27.

Genipin ((+)-Genipin)

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物理化学性质&存储条件

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Genipin ((+)-Genipin)

生物&药学活性

物理化学性质&存储条件

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