Gemigliptin |CAS:911637-19-9 Probechem Biochemicals

Chemical Structure : Gemigliptin

CAS No.: 911637-19-9

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Gemigliptin (LC15-0444;LC150444;LC 150444)

货号: PC-60974Not For Human Use, Lab Use Only.

Gemigliptin (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.

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25 mg	￥1980	In stock
50 mg	￥3280	In stock
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生物&药学活性

Gemigliptin (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.
Gemigliptin exhibits potent anti-glycation properties in vitro and in vivo, also improves renal function and attenuates podocyte injury in mice with diabetic nephropathy.

物理化学性质&存储条件

分子量	489.37
分子式	C18H19F8N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

参考文献

1. Lim KS, et al. Br J Clin Pharmacol. 2009 Dec;68(6):883-90.

2. Hwang HJ, et al. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):1-7.

3. Jung E, et al. Eur J Pharmacol. 2014 Dec 5;744:98-102.

4. Jung E, et al. Eur J Pharmacol. 2015 Aug 15;761:116-24.

Gemigliptin (LC15-0444;LC150444;LC 150444)

生物&药学活性

物理化学性质&存储条件

参考文献

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Gemigliptin (LC15-0444;LC150444;LC 150444)

生物&药学活性

物理化学性质&存储条件

参考文献

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