Gemcabene calcium |CAS:209789-08-2 Probechem Biochemicals

Chemical Structure : Gemcabene calcium

CAS No.: 209789-08-2

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Gemcabene calcium (PD-72953;PD72953)

货号: PC-35646Not For Human Use, Lab Use Only.

Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Gemcabene (PD-72953, PD72953) calcium is a first-in-class lipid-lowering agent and activator of PARP.
Gemcabene down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM.
Gemcabene lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.

物理化学性质&存储条件

分子量	340.473
分子式	C16H28CaO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid calcium salt

参考文献

1. Bisgaier CL, et al. J Lipid Res. 1998 Jan;39(1):17-30.

2. Bays HE, et al. Am J Cardiol. 2003 Sep 1;92(5):538-43.

3. Yuan H, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):191-7.

4. Srivastava RAK, et al. Front Pharmacol. 2018 May 11;9:471.

Gemcabene calcium (PD-72953;PD72953)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Gemcabene calcium (PD-72953;PD72953)

生物&药学活性

物理化学性质&存储条件

参考文献

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