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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-Gefitinib hydrochloride
Gefitinib hydrochloride

Chemical Structure : Gefitinib hydrochloride

CAS No.: 184475-55-6

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Gefitinib hydrochloride (ZD-1839 hydrochloride, ZD1839 hydrochloride)

货号: PC-45892Not For Human Use, Lab Use Only.

Gefitinib hydrochloride (ZD1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.

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100 mg ￥480 In stock
500 mg ￥780 In stock
1 g ￥1180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Gefitinib hydrochloride (ZD1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.
Gefitinib inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM.
Gefitinib blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50 of 0.2-0.4 uM.
Gefitinib significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth.
Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer.

物理化学性质&存储条件

分子量 483.3633
分子式 C22H25Cl2FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 0.227 mg/mL; H2O：< 4.8 mg/mL
Chemical Name/SMILES

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:1)

参考文献

1. Barker AJ, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4.

2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.

3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.

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