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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-ATP Synthase-Gboxin
Gboxin

Chemical Structure : Gboxin

CAS No.: 2101315-36-8

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Gboxin (Oxidative phosphorylation inhibitor)

货号: PC-36144Not For Human Use, Lab Use Only.

Gboxin is a small molecule oxidative phosphorylation inhibitor that specifically inhibits the growth of primary mouse and human glioblastoma cells, but not cycling primary MEFs or astrocytes.

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10 mg ￥1980 In stock
25 mg ￥2980 In stock
100 mg ￥5880 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Gboxin is a small molecule oxidative phosphorylation inhibitor that specifically inhibits the growth of primary mouse and human glioblastoma cells, but not cycling primary MEFs or astrocytes.
Gboxin inhibits cellular oxygen consumption and interacts with GBM OxPhos proteins, mirrors oligomycin activity and resistance requires functional mPTP.
Gboxin specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM) but not that of mouse embryonic fibroblasts or neonatal astrocytes.
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma, inhibits the activity of F0F1 ATP synthase, mirrors oligomycin activity and resistance requires functional mPTP.
Gboxin targets unique features of mitochondrial pH in GBM and other cancer cells, independent of their genetic composition, and exerts its tumor cell specific toxicity in primary culture and in vivo.

物理化学性质&存储条件

分子量 392.968
分子式 C22H33ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride

参考文献

1. Shi Y, et al. Nature. 2019 Mar;567(7748):341-346.

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