Garcinol |CAS:78824-30-3 Probechem Biochemicals

Chemical Structure : Garcinol

CAS No.: 78824-30-3

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Garcinol (Camboginol)

货号: PC-62558Not For Human Use, Lab Use Only.

Garcinol (Camboginol) is a potent, natural inhibitor of histone acetyltransferases (HATs) p300 (IC50=7 uM) and PCAF (IC50=5 uM) both in vitro and in vivo.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Garcinol (Camboginol) is a potent, natural inhibitor of histone acetyltransferases (HATs) p300 (IC50=7 uM) and PCAF (IC50=5 uM) both in vitro and in vivo.
Garcinol (Camboginol) downregulates various cell survival proteins including survivin, bcl-2, XIAP, and cFLIP, and induces bid cleavage, bax, and cytochrome c release.
Garcinol (Camboginol) potentiates TRAIL-induced apoptosis through upregulation of death receptors and downregulation of antiapoptotic proteins.
Garcinol (Camboginol) also siimulates neurogenesis and ex vivo expansion of human hematopoietic stem cells.

物理化学性质&存储条件

分子量	602.812
分子式	C38H50O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione

参考文献

1. Balasubramanyam K, et al. J Biol Chem. 2004 Aug 6;279(32):33716-26.

2. Prasad S, et al. Mol Cancer Ther. 2010 Apr;9(4):856-68.

3. Nishino T, et al. PLoS One. 2011;6(9):e24298.

Garcinol (Camboginol)

生物&药学活性

物理化学性质&存储条件

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Garcinol (Camboginol)

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