Ganfeborole hydrochloride

Chemical Structure : Ganfeborole hydrochloride

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货号: PC-25241Not For Human Use, Lab Use Only.

Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
GSK3036656 displays no significant activity for human mitochondrial LeuRS and human cytoplasmic LeuRS (IC50>100 uM).
GSK3036656 shows potent antitubercular activity (Mtb H37Rv IC50=0.08 uM) in vitro.
GSK3036656 exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models.

物理化学性质&存储条件

分子量	293.94
分子式	C10H14BCl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

参考文献

1. Li X,et al. J Med Chem. 2017 Oct 12;60(19):8011-8026.