Galinex

Chemical Structure : Galinex

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货号: PC-27135Not For Human Use, Lab Use Only.

Galinex is a highly potent, selective GPR17 agonist with EC50 of 0.64 nM, Emax=127.8% in [35S]GTPγS functional assays in membranes from 1321N1 cells transfected with human GPR17.

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生物&药学活性

Galinex is a highly potent, selective GPR17 agonist with EC50 of 0.64 nM, Emax=127.8% in [35S]GTPγS functional assays in membranes from 1321N1 cells transfected with human GPR17.
Galinex at 0.1 uM exhibits no significant pharmacological activity on 40 GPCRs including purinergic P2Yn, CysLT1 and CysLT2 and chemokine receptor sub-families.
Galinex shows protective activity on experimental autoimmune encephalomyelitis (EAE) development in vivo in the EAE mouse model.
Galinex can promote oligodendrocyte maturation and wrapping features under non-permissive inflammatory conditions.

物理化学性质&存储条件

分子量	331.41
分子式	C14H13N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(thiazol-2-yl)-2-((5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide

参考文献

1. Parravicini C, et al. PLoS One. 2020 Apr 22;15(4):e0231483.

2. Castro E Silva JH, et al. Front Pharmacol. 2026 Jun 5;17:1838997.

Galinex

生物&药学活性

物理化学性质&存储条件

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Galinex

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物理化学性质&存储条件

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