Galiellalactone |CAS:133613-71-5 Probechem Biochemicals

Chemical Structure : Galiellalactone

加入收藏

Galiellalactone

货号: PC-61140Not For Human Use, Lab Use Only.

Galiellalactone is a small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA.

规格	价格	库存	数量
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Galiellalactone is a small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA.
Galiellalactone induces apoptosis of p-Stat3 positive PCa cells, and Stat3-mediated transcription with IC50 of 5 uM, reduces the expression of Bcl-2, Bcl-x(L), c-myc, and cyclin D1.
Galiellalactone covalently binds to one or more cysteines in STAT3 and inhibits STAT3 binding to DNA and thus blocks STAT3 signaling without affecting phosphorylation.
Galiellalactone reduces tumor growth and decreases lymph node metastases in mice model of prostate cancer.

物理化学性质&存储条件

分子量	194.2
分子式	C11H14O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one

参考文献

1. Weidler M, et al. FEBS Lett. 2000 Oct 27;484(1):1-6.

2. Canesin G, et al. Eur Urol. 2016 Mar;69(3):400-4.

3. Don-Doncow N, et al. J Biol Chem. 2014 Jun 6;289(23):15969-78.

4. Hellsten R, et al. Prostate. 2008 Feb 15;68(3):269-80.