Galanthamine |CAS:357-70-0 Probechem Biochemicals

Chemical Structure : Galanthamine

CAS No.: 357-70-0

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Galanthamine

货号: PC-45968Not For Human Use, Lab Use Only.

A potent allosteric potentiating ligand of human nAChRs α4β2, α3β4, and α6β4.

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100 mg	￥640	In stock

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生物&药学活性

A potent allosteric potentiating ligand of human nAChRs α4β2, α3β4, and α6β4; potentiates agonist responses of the four nAChR subtypes at 0.1-1 uM, acts as an nAChR inhibitor at >10 uM; also shows affinity for chicken/mouse nAChRs α7/5-HT3 in certain areas of the brain; also works as a weak competitive and reversible cholinesterase inhibitor with IC50 of 2.8-3.2 uM; decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line.

Alzheimer's Disease

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物理化学性质&存储条件

分子量	287.3535
分子式	C17H21NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 59 mg/mL
Chemical Name/SMILES	6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-

参考文献

1. Samochocki M, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1024-36.

2. Woodruff-Pak DS, et al. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2089-94.

3. Bloniecki V, et al. J Alzheimers Dis. 2017;57(2):387-393.

Galanthamine

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物理化学性质&存储条件

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Galanthamine

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