GZNL-P36

Chemical Structure : GZNL-P36

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货号: PC-23545Not For Human Use, Lab Use Only.

GZNL-P36 is a potent, selective and orally bioavailable SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 6.45 nM, ITC Kd value of 24.6 nM.

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生物&药学活性

GZNL-P36 is a potent, selective and orally bioavailable SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 6.45 nM, ITC Kd value of 24.6 nM.
GZNL-P36 dose-dependently protects cells from death with 50% effective concentration (EC50) values for wild type (WT), Omicron BA.5 and XBB.1 is 111.0 nM, 306.2 nM and 58.2 nM, respectively.
GZNL-P36 possesses similar effective anti-viral activity for SARS-CoV-2 and its variants, compared with S-217622 (Ensitrelvir).
GZNL-P36 also exhibits anti-viral activity for the other coronaviruses, such as HCoV-NL63 (EC50: 81.6 nM) and HCoV-229E (EC50: 2.66 μM).
Oral administration of the GZNL-P36 results in significantly improved survival and notable reductions in lung viral loads and lesions in SARS-CoV-2 infection mouse model, consistent with RNA-seq data analysis.

物理化学性质&存储条件

分子量	466.59
分子式	C29H30N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-N-(1-(1-methyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)cyclopropyl)-5-(6-methyl-3,6-diazabicyclo[3.1.1]heptan-3-yl)benzamide

参考文献

1. Lu Y, et al. Nat Commun. 2024 Nov 23;15(1):10169.

GZNL-P36

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物理化学性质&存储条件

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GZNL-P36

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物理化学性质&存储条件

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