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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-GZ-794A
GZ-794A

Chemical Structure : GZ-794A

CAS No.: 1392205-38-7

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GZ-794A (GZ794A)

货号: PC-47109Not For Human Use, Lab Use Only.

GZ-794A is a potent, selective inhibitor of vesicular monoamine transporter-2 (VMAT2) with Ki of 30 nM, inhibits methamphetamine-evoked endogenous dopamine release with IC50 of 0.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GZ-794A is a potent, selective inhibitor of vesicular monoamine transporter-2 (VMAT2) with Ki of 30 nM, inhibits methamphetamine-evoked endogenous dopamine release with IC50 of 0.4 uM.
    GZ-794A shows potential for treatment for methamphetamine abuse.

    物理化学性质&存储条件

    分子量 467.653
    分子式 C32H37NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-3-[2,6-cis-di(1-naphthylethyl)piperidin-1-yl]propane-1,2-diol

    参考文献

    1. Horton DB, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):286-97.

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