GZ-793A | VMAT2 inhibitor | Probechem Biochemicals

Chemical Structure : GZ-793A

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GZ-793A (GZ793A)

货号: PC-47108Not For Human Use, Lab Use Only.

GZ-793A is a potent, selective inhibitor of vesicular monoamine transporter-2 (VMAT2) with Ki of 30 nM, inhibits methamphetamine-evoked endogenous dopamine release with IC50 of 10.6 uM.

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生物&药学活性

GZ-793A is a potent, selective inhibitor of vesicular monoamine transporter-2 (VMAT2) with Ki of 30 nM, inhibits methamphetamine-evoked endogenous dopamine release with IC50 of 10.6 uM.
GZ-793A (15 mg/kg, s.c.) specifically decreased methamphetamine (METH) self-administration, without the development of tolerance.
GZ-793A did not serve as a substitute for self-administered METH.
GZ-793A blocked METH-induced conditioned place preference (CPP) and did not induce CPP alone.

物理化学性质&存储条件

分子量	464.043
分子式	C26H38ClNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxyphenethyl)piperidine hydrochloride

参考文献

1. Beckmann JS, et al. Psychopharmacology (Berl). 2012 Mar;220(2):395-403.

2. Horton DB, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):286-97.

GZ-793A (GZ793A)

生物&药学活性

物理化学性质&存储条件

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GZ-793A (GZ793A)

生物&药学活性

物理化学性质&存储条件

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