GZ-11608 | VMAT2 inhibitor | Probechem Biochemicals

Chemical Structure : GZ-11608

加入收藏

GZ-11608 (GZ11608)

货号: PC-47107Not For Human Use, Lab Use Only.

GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with Ki of 25 nM, GZ-11608 (EC50=620 nM) released vesicular dopamine 25-fold less potently than it inhibited VMAT2 dopamine uptake.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with Ki of 25 nM, GZ-11608 (EC50=620 nM) released vesicular dopamine 25-fold less potently than it inhibited VMAT2 dopamine uptake.
GZ-11608 displays selectivity (92-1180-fold) for VMAT2 over nicotinic receptors, dopamine transporter, and hERG, suggesting low side-effects.
GZ-11608 competitively inhibited methamphetamine-evoked vesicular dopamine release.
GZ-11608 decreased methamphetamine sensitization without altering striatal dopamine content or exacerbating methamphetamine-induced dopamine depletion, revealing efficacy without neurotoxicity.
GZ-11608 exhibited linear pharmacokinetics and rapid brain penetration.
GZ-11608 decreased methamphetamine self-administration in drug-naive rats.

物理化学性质&存储条件

分子量	283.415
分子式	C19H25NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine

参考文献

1. Lee NR, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):526-543.

GZ-11608 (GZ11608)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GZ-11608 (GZ11608)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.