GY101 | TLR7 agonist | Probechem Biochemicals

Chemical Structure : GY101

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GY101 (GY-101)

货号: PC-22025Not For Human Use, Lab Use Only.

GY101 is a potent, selective TLR7 agonist, activates the TLR7/NF-κB signaling pathway with EC50 of 0.15 uM.

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1 g		Get quote

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生物&药学活性

GY101 is a potent, selective TLR7 agonist, activates the TLR7/NF-κB signaling pathway with EC50 of 0.15 uM.
GY101 does not stimulate TLR8/NF-κB signaling even at 40 uM.
GY101 (0.1-20 uM) promotes the production of IL-6, IL-12, TNF-α and IFN-γ in a concentration-dependent manner in mouse spleen lymphocytes.
GY101 exerts no direct effect on tumor cells.
GY101 suppresses the growth of colon cancer in mice model of B16–F10 and 4T1 and activates the antitumor immune response.
GY101 increases the proportion of CD4⁺ and CD8⁺ T cells and promotes the polarization of macrophages to the M1 type.

物理化学性质&存储条件

分子量	494.51
分子式	C20H30N8O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(2-(2-(4-((6-amino-2-butoxy-8-hydroxy-9H-purin-9-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)acetic acid

参考文献

1. Su-Mei Ren, et al. Eur J Pharmacol. 2024 Mar 15:967:176383.

GY101 (GY-101)

生物&药学活性

物理化学性质&存储条件

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GY101 (GY-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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