GY1-22 | DNAJA1-mutp53R175H inhibitor | Probechem Biochemicals

Chemical Structure : GY1-22

加入收藏

GY1-22 (DNAJA1-mutP53 R175H inhibitor)

货号: PC-49512Not For Human Use, Lab Use Only.

GY1-22 is a small molecule inhibitor against DNAJA1-mutP53R175H interacting pocket, reduces mutp53 protein expression in colon cancer cell line with p53R175H mutation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GY1-22 is a small molecule inhibitor against DNAJA1-mutP53R175H interacting pocket, reduces mutp53 protein expression in colon cancer cell line with p53R175H mutation.
GY1-22 specifically disrupts the binding between mutp53 and DNAJA1, with no effect on antaxin-3, another protein that has been reported to bind to DNAJA1.
GY1-22 exhibited a dose-dependent effect on inhibition of mutp53 and cyclin D1 expression but induction of wtp53-activated Waf1p21 expression in P03 cells (derived from mice carrying both wtp53 and mutp53 R172H, equivalent to human mutp53R175H), inhibited cell growth with IC50 of 28 uM.
GY1-22 (1 mg/kg, i.p. injection) showed a significant inhibition of in vivo tumor growth in P03 subcutaneous implanted in C57BL/6J mice.

物理化学性质&存储条件

分子量	400.50
分子式	C23H20N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2- {2-[(1H benzimidazol-2-ylmethyl)sulfanyl]-1H-benzimidazol-1-yl}ethyl phenyl ether

参考文献

1. Tong X, et al. J Biol Chem. 2021 Jan-Jun;296:100098.