GW 806742X |CAS:579515-63-2 Probechem Biochemicals

Chemical Structure : GW 806742X

CAS No.: 579515-63-2

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GW 806742X (T0466, GW806742X)

货号: PC-70325Not For Human Use, Lab Use Only.

GW 806742X (T0446) is a small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

GW 806742X (T0446) is a small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis.
GW 806742X rescues 50% of wild-type MDFs from TSQ-induced necroptosis with IC50 <50 nM, with >50-fold greater potency than Nec-1.
GW 806742X enhances RIPK3-mediated phosphorylation of MLKL (S345 and S347) at 10 uM.
GW 806742X (T0446) also activates PINK1-Parkin signaling, induces Parkin mitochondrial translocation in dopaminergic neurons differentiated from iPS cells (iPSCs) without obvious ΔΨm reduction and cell toxicity.

物理化学性质&存储条件

分子量	573.551
分子式	C25H22F3N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide

参考文献

1. Hildebrand JM, et al. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7.
2. Shiba-Fukushima K, et al. iScience. 2020 May 22;23(5):101048.

GW 806742X (T0466, GW806742X)

生物&药学活性

物理化学性质&存储条件

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GW 806742X (T0466, GW806742X)

生物&药学活性

物理化学性质&存储条件

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