GW803430 | MCHR1 inhibitor | Probechem Biochemicals

Chemical Structure : GW803430

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GW803430 (GW803430, GW-803430)

货号: PC-61120Not For Human Use, Lab Use Only.

GW803430 is a potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1) inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes.

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生物&药学活性

GW803430 is a potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1) inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes.
GW803430 produces robust antidepressant-like response in mice (0.3 and 1 mg/kg p.o.).
GW803430 also significantly reduces submissive behaviors and shows anxiolytic-like effects in vivo.

物理化学性质&存储条件

分子量	481.995
分子式	C25H24ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

参考文献

1. Gehlert DR, et al. J Pharmacol Exp Ther. 2009 May;329(2):429-38.

2. Cippitelli A, et al. Psychopharmacology (Berl). 2010 Sep;211(4):367-75.

3. Zhang LN, et al. Obesity (Silver Spring). 2014 Mar;22(3):681-90.

4. Hertzog DL, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7.

GW803430 (GW803430, GW-803430)

生物&药学活性

物理化学性质&存储条件

参考文献

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GW803430 (GW803430, GW-803430)

生物&药学活性

物理化学性质&存储条件

参考文献

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