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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-GW791343
GW791343

Chemical Structure : GW791343

CAS No.: 1019779-04-4

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GW791343 (GW791343 dihydrochloride)

货号: PC-25894Not For Human Use, Lab Use Only.

GW791343 dihydrochloride is a selective, allosteric antagonist with negative allosteric effects at the human P2X7 receptor with pIC50 of 6.9-7.2, but is a positive allosteric modulator of the rat P2X(7) receptor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GW791343 dihydrochloride is a selective, allosteric antagonist with negative allosteric effects at the human P2X7 receptor with pIC50 of 6.9-7.2, but is a positive allosteric modulator of the rat P2X(7) receptor.

物理化学性质&存储条件

分子量 447.35
分子式 C20H26Cl2F2N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3,4-Difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride

参考文献

1. Michel AD, et al. Br J Pharmacol. 2008 Feb;153(4):737-50.

2. Michel AD, et al. Br J Pharmacol. 2008 Nov;155(5):738-51.

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