GW782415W | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : GW782415W

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GW782415W (GW782415)

货号: PC-20731Not For Human Use, Lab Use Only.

GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively.

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生物&药学活性

GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively.
GW782415W ablates both the early and late phase reactions in a mouse model of allergic conjunctivitis.
Systemic administration of GW782415X reduced spontaneous CNV in JR5558 mice and laser-induced CNV in mouse and primate models in a dose-dependent fashion.

物理化学性质&存储条件

分子量	414.29
分子式	C16H21Cl2N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NCC1=NN(C)N=N1)NC[C@H]2CN(CC3=CC=C(Cl)C(Cl)=C3)CCO2

参考文献

1. Takao Nakamura, et al. Immunol Res. 2005;33(3):213-21.

2. Nori Nagai, et al. Am J Pathol. 2015 Sep;185(9):2534-49.

3. Neda Farahi, et al. J Immunol. 2007 Jul 15;179(2):1264-73.

GW782415W (GW782415)

生物&药学活性

物理化学性质&存储条件

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GW782415W (GW782415)

生物&药学活性

物理化学性质&存储条件

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