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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-GW 766994
GW 766994

Chemical Structure : GW 766994

CAS No.: 408303-43-5

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GW 766994 (GW766994)

货号: PC-35226Not For Human Use, Lab Use Only.

GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
GW-766994 reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3.
GW-766994 blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.

物理化学性质&存储条件

分子量 451.348
分子式 C21H24Cl2N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide

参考文献

1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.

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