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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-GW627368
GW627368

Chemical Structure : GW627368

CAS No.: 439288-66-1

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GW627368 (GW627368X)

货号: PC-45103Not For Human Use, Lab Use Only.

GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor with pKi of 7.0.

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10 mg ￥1580 In stock
25 mg ￥2680 In stock
50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor with pKi of 7.0.
GW627368 also binds to human prostanoid TP receptors (pKi=6.8) but not the TP receptors of other species.
GW627368 produces 100% inhibition of U-46619 (EC100)-induced aggregation at 10 uM (pA2=7.0).
GW627368 also inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling.

物理化学性质&存储条件

分子量 544.6181
分子式 C30H28N2O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzeneacetamide, 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-

参考文献

1. Wilson RJ, et al. Br J Pharmacol. 2006 Jun;148(3):326-39.

2. Parida S, et al. Cell Death Dis. 2016 Mar 24;7:e2154.

3. Parida S, et al. Cancer Biol Ther. 2015;16(6):922-32.

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