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首页-小分子抑制剂&激动剂-Apoptosis-RIP kinase-GW440139B
GW440139B

Chemical Structure : GW440139B

CAS No.: 955879-75-1

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GW440139B (GW 440139B)

货号: PC-72529Not For Human Use, Lab Use Only.

GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM.
    GW440139B inhibits TNF- and TRIF-mediated necroptosis independent of RIPK1-RIPK3 interaction, directly inhibited RIPK3-mediated MLKL phosphorylation at Ser345, thus inhibiting necroptosis.

    物理化学性质&存储条件

    分子量 327.387
    分子式 C21H17N3O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-methyl-3-((7-(pyridin-2-yl)quinolin-4-yl)amino)phenol

    参考文献

    1. D A Rodriguez, et al. Cell Death Differ. 2016 Jan;23(1):76-88.

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