GW406108X | Kif15 inhibitor | Probechem Biochemicals

Chemical Structure : GW406108X

CAS No.: 1644443-92-4

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GW406108X (GW-406108X;GW108X)

货号: PC-35945Not For Human Use, Lab Use Only.

GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays.
GW108X displays a preference for Kif15 over the other mitotic motors, with 30 µM of GW108X inhibiting Kif15 MT gliding by 98.9% ± 0.2% while only inhibiting Eg5 by 19.8% ± 4.3%, HSET by 5.3% ± 2.9% and Kif18A by 4.9%.
GW406108X inhibits the MT-stimulated ATPase and MT gliding activity of Kif15 either by inhibiting ATP binding or by inhibiting MT binding by the motorl.
GW406108X shows a distinct mechanism of action compared with the Kif15 inhibitor, Kif15-IN-1.

物理化学性质&存储条件

分子量	400.211
分子式	C20H11Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(3,5-dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one

参考文献

1. Dumas ME, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):148-154.

GW406108X (GW-406108X;GW108X)

生物&药学活性

物理化学性质&存储条件

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GW406108X (GW-406108X;GW108X)

生物&药学活性

物理化学性质&存储条件

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