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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-GW405833
GW405833

Chemical Structure : GW405833

CAS No.: 180002-83-9

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GW405833 (L768242)

货号: PC-24076Not For Human Use, Lab Use Only.

GW405833 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.

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10 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GW405833 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
GW405833 causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM.
GW405833 elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.

物理化学性质&存储条件

分子量 447.36
分子式 C23H24Cl2N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone

参考文献

1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.

2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.

3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.

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