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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-GW3965 hydrochloride
GW3965 hydrochloride

Chemical Structure : GW3965 hydrochloride

CAS No.: 405911-17-3

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GW3965 hydrochloride (GW 3965 hydrochloride;GW-3965 hydrochloride)

货号: PC-42686Not For Human Use, Lab Use Only.

GW3965 hydrochloride is a potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GW3965 hydrochloride is a potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM.
GW3965 acts as a full agonist on hLXRα and hLXRβ in cell-based reporter gene assays with EC50 of 190 and 30 nM, respectively.
GW3965 increases expression of ABCA1 in the small intestine and peripheral macrophages in C57BL/6 mice at 10 mg/kg.

物理化学性质&存储条件

分子量 618.5133
分子式 C33H32Cl2F3NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride (1:1)

参考文献

1. Collins JL, et al. J Med Chem. 2002 May 9;45(10):1963-6.

2. Joseph SB, et al. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9.

3. Donkin JJ, et al. J Biol Chem. 2010 Oct 29;285(44):34144-54.

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