GW3965 |CAS:405911-09-3 Probechem Biochemicals

Chemical Structure : GW3965

CAS No.: 405911-09-3

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GW3965 (GW 3965;GW-3965)

货号: PC-42685Not For Human Use, Lab Use Only.

GW3965 is a potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

GW3965 is a potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM.
GW3965 acts as a full agonist on hLXRα and hLXRβ in cell-based reporter gene assays with EC50 of 190 and 30 nM, respectively.
GW3965 increases expression of ABCA1 in the small intestine and peripheral macrophages in C57BL/6 mice at 10 mg/kg.

物理化学性质&存储条件

分子量	582.0524
分子式	C33H31ClF3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-

参考文献

1. Collins JL, et al. J Med Chem. 2002 May 9;45(10):1963-6.

2. Joseph SB, et al. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9.

3. Donkin JJ, et al. J Biol Chem. 2010 Oct 29;285(44):34144-54.

GW3965 (GW 3965;GW-3965)

生物&药学活性

物理化学性质&存储条件

参考文献

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GW3965 (GW 3965;GW-3965)

生物&药学活性

物理化学性质&存储条件

参考文献

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