GW311616A | Neutrophil elastase inhibitor | Probechem Biochemicals

Chemical Structure : GW311616A

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GW311616A (GW-311616A)

货号: PC-49568Not For Human Use, Lab Use Only.

GW311616A is a potent, specifc intracellular and orally active inhibitor of human neutrophil elastase (HNE) with Ki of 0.31 nM.

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生物&药学活性

GW311616A is a potent, specifc intracellular and orally active inhibitor of human neutrophil elastase (HNE) with Ki of 0.31 nM.
GW311616A significantly reduced injury-induced neointimal hyperplasia (NIH) in both neutrophil elastase-deficient mice and mice.
GW311616A reversed insulin resistance and body weight gain in HFD-fed mice.

物理化学性质&存储条件

分子量	397.53
分子式	C19H31N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]pyrrolo[3,2-b]pyrrol-2(1H)-one

参考文献

1. Macdonald SJ, et al. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.

2. Mansuy-Aubert V, et al. Cell Metab. 2013 Apr 2;17(4):534-48.

3. Mei Yang, et al. Br J Pharmacol. 2021 Oct;178(20):4048-4068.

GW311616A (GW-311616A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GW311616A (GW-311616A)

生物&药学活性

物理化学性质&存储条件

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