GW280264X | ADAM10/17 inhibitor | Probechem Biochemicals

Chemical Structure : GW280264X

CAS No.: 866924-39-2

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GW280264X (GW 280264X)

货号: PC-73156Not For Human Use, Lab Use Only.

GW280264X is a potent, dual ADAM10/TACE (ADAM17) metalloproteinases inhibitor with IC50 of 8.0 nM and 11.5 nM, respectively.

规格	价格	库存
1 mg	￥1580	In stock
5 mg	￥3580	In stock
10 mg	￥5980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

GW280264X is a potent, dual ADAM10/TACE (ADAM17) metalloproteinases inhibitor with IC50 of 8.0 nM and 11.5 nM, respectively.
GW280264X is an effective inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage in CX3CL1-expressing ECV-304 cells.
GW280264X blocked IL-6-induced proliferation and ERK1/2 phosphorylation with same potency as GM6001 in non-transformed prostate epithelial cells.
GW280264X enhances platinum efficiency in ovarian cancer.

物理化学性质&存储条件

分子量	575.72
分子式	C28H41N5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzyl ((S)-5-((2R,3S)-3-(N-hydroxyformamido)-2-isobutylhexanamido)-6-oxo-6-(thiazol-2-ylamino)hexyl)carbamate

参考文献

1. Budagian V, et al. J Biol Chem. 2004 Sep 24;279(39):40368-75.

2. Hundhausen C, et al. Blood. 2003 Aug 15;102(4):1186-95.

3. Rabie T, et al. J Biol Chem. 2005 Apr 15;280(15):14462-8.

4. Bourd-Boittin K, et al. J Cell Mol Med. 2009 Aug;13(8A):1526-35.

GW280264X (GW 280264X)

生物&药学活性

物理化学性质&存储条件

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GW280264X (GW 280264X)

生物&药学活性

物理化学性质&存储条件

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