GW274150 |CAS:210354-22-6 Probechem Biochemicals

Chemical Structure : GW274150

CAS No.: 210354-22-6

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GW274150 (GW-274150;GW 274150)

货号: PC-42897Not For Human Use, Lab Use Only.

GW274150 is a potent and highly selective inhibitor of iNOS with IC50 of 1.4 uM, displays >200 fold selectivity over eNOS and nNOS (IC50>100 uM).

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

GW274150 is a potent and highly selective inhibitor of iNOS with IC50 of 1.4 uM, displays >200 fold selectivity over eNOS and nNOS (IC50>100 uM).
GW274150 attenuates the degree of chronic inflammation and tissue damage associated with collagen-induced arthritis in mice.
GW274150 significantly reduces serum urea, serum creatinine, AST, and NAG, reduces experimental renal ischemia/reperfusion injury.

物理化学性质&存储条件

分子量	219.3045
分子式	C8H17N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 62 mg/mL
Chemical Name/SMILES	L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-

参考文献

1. Young RJ, et al. Bioorg Med Chem Lett. 2000 Mar 20;10(6):597-600.

2. Cuzzocrea S, et al. Eur J Pharmacol. 2002 Oct 18;453(1):119-29.

3. McDonald MC, et al. J Physiol Pharmacol. 2002 Dec;53(4 Pt 1):555-69.

4. Chatterjee PK, et al. Kidney Int. 2003 Mar;63(3):853-65.

GW274150 (GW-274150;GW 274150)

生物&药学活性

物理化学性质&存储条件

参考文献

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GW274150 (GW-274150;GW 274150)

生物&药学活性

物理化学性质&存储条件

参考文献

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