GW0742 | PPARδ agonist | Probechem Biochemicals

Chemical Structure : GW0742

CAS No.: 317318-84-6

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GW0742 (GW610742)

货号: PC-22387Not For Human Use, Lab Use Only.

GW0742 is a potent, selective small molecule agonist of PPARδ with EC50 of 1.0 nM, 1000-fold selectivity over the other human PPAR subtypes.

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5 mg (Free Sample)	￥280	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

GW0742 is a potent, selective small molecule agonist of PPARδ with EC50 of 1.0 nM, 1000-fold selectivity over the other human PPAR subtypes.
GW0742 can restore partly the expression of certain key genes of fatty acid oxidation in mouse adult cardiomyocytes isolated from PPARalpha knockout mice.
GW0742 significantly reduces cell death during a 12-hr exposure to low-KCl media in rat cultured cerebellar granule neurons.

物理化学性质&存储条件

分子量	471.48
分子式	C21H17F4NO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid

参考文献

1. Sznaidman ML, et al. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21.

2. Cheng L, et al. Biochem Biophys Res Commun. 2004 Jan 9;313(2):277-86.

3. Smith SA, et al. J Neurosci Res. 2004 Jul 15;77(2):240-9.

GW0742 (GW610742)

生物&药学活性

物理化学性质&存储条件

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GW0742 (GW610742)

生物&药学活性

物理化学性质&存储条件

参考文献

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