GW-1100 |CAS:306974-70-9 Probechem Biochemicals

Chemical Structure : GW-1100

CAS No.: 306974-70-9

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GW-1100 (SB-376752)

货号: PC-45843Not For Human Use, Lab Use Only.

GW-1100 (SB-376752) is a potent, selective GPR40 antagonist that dose dependently inhibits GPR40-mediated Ca2+ elevations stimulated by GW9508 and linoleic acid with pIC50 of 5.99.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GW-1100 (SB-376752) is a potent, selective GPR40 antagonist that dose dependently inhibits GPR40-mediated Ca2+ elevations stimulated by GW9508 and linoleic acid with pIC50 of 5.99.
GW-1100 (SB-376752) has no effect on the GPR120-mediated stimulation of intracellular Ca2+ release.
GW-1100 (SB-376752) reverses the KCl-mediated increase in insulin secretion in MIN6 cells potentiated by GW9508.
GW-1100 (SB-376752) increases formalin-induced pain-related behaviour in mice.

物理化学性质&存储条件

分子量	520.5752
分子式	C27H25FN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-, ethyl ester

参考文献

1. Briscoe CP, et al. Br J Pharmacol. 2006 Jul;148(5):619-28.

2. Stoddart LA, et al. Mol Pharmacol. 2007 Apr;71(4):994-1005.

3. Nakamoto K, et al. Br J Pharmacol. 2015 Mar;172(5):1250-62.

GW-1100 (SB-376752)

生物&药学活性

物理化学性质&存储条件

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GW-1100 (SB-376752)

生物&药学活性

物理化学性质&存储条件

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